Normalization of striatal tyrosine hydroxylase and reversal of motor impairment in experimental parkinsonism with intravenous nonviral gene therapy and a brain-specific promoter
For the body to resist these damages, it possesses a range of endogenous antioxidants, primarily enzymatic antioxidants (superoxide dismutase (SOD), glutathione peroxidase (GPX), glutathione S-transferase (GST), glutathione reductase (GR), thioredoxin reductase (TrxR), catalase (CAT), etc.), and nonenzymatic antioxidants (glutathione (GSH), bilirubin, ubiquinone, etc.) [11]
In particular, lower levels of adiponectin and increased expression of TNF- and its soluble receptor have been recently related to the development of NASH ( Most patients with NAFLD are asymptomatic, and the diagnosis is mainly made incidentally on the basis of liver biochemistry or abdominal ultrasound abnormalities
Integrating ChIP-seq, HiC, and PRO-seq datasets, we revealed broad functional binding of NRF2 at enhancer elements, including NRF2-dependent enhancer-derived RNA (eRNA) synthesis and extensive linkages between NRF2 target promoters and enhancers
Hadzhieva M, Kirches E, Wilisch-Neumann A, Pachow D, Wallesch M, Schoenfeld P et al (2013) Dysregulation of iron protein expression in the G93A model of amyotrophic lateral sclerosis
